One of their Ovomorphs was stolen and an entire small Xenomorph hive was wiped out. In Aliens: Music of the Spears #1 by Chet Williamson and Tim Hamilton, a pharmaceutical company that refined drugs from the Royal Jelly derived from Ovomorphs was robbed. If the Predators used this secret weakness in question, however, any negative impacts associated with their wrist bombs wouldn’t be a problem, as the Xenomorphs would simply be ravaging each other.

Unfortunately, this also kills any other Yautja who’s still fighting, while also decimating the area in which the hunt is actually taking place. However, if things do get out of hand during a hunt and the Xenomorphs actually manage to conquer the Predators, the Yuatja will use their wrist bombs to eradicate any living Xenomorph in the area. Most Alien vs Predator stories center around the Blooding Ritual–which dictates a Predator kill a Xenomorph in order to be considered a mature member of the clan–including the 2004 film, and that’s because Predators have no real reason to kill Xenomorphs other than to prove their mettle to the rest of their species. Yautja hunt Xenomorphs as a part of their religion, in a ritualistic hunt known as the Blooding Ritual. Predators have been hunting Xenomorphs for eons within the extended Alien continuity, but even they don’t know their secret weakness–one that doesn’t even require them to fire a single shot, or brandish a single blade.

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